范松

寄語

敬畏生命！感恩這份職責！
盡心做好每一例手術(shù)，不斷超越和突破，既是自身職責更是對頜面外科......

專業(yè)擅長

口腔頜面-頭頸良惡性腫瘤，包括舌癌、牙齦癌、頰癌、口咽癌、頜骨腫瘤以及涎腺腫瘤等免疫治療以及手術(shù)切除和同期功能性修復重建(股前外側(cè)瓣、腓骨肌皮瓣、腓骨肌筋膜瓣、前臂瓣、胸大肌瓣等各種游離和帶蒂組織瓣)；頜骨放射性骨壞死修復重建；頜面頸部內(nèi)鏡微創(chuàng)手術(shù)；血管瘤和脈管畸形綜合治療；顱頜面外傷救治。

個人簡介

范松 醫(yī)學博士口腔科副主任 博士研究生導師羊城好醫(yī)生美國癌癥研究協(xié)會(AACR)會員哈佛大學麻省總院腫瘤外科博士后廣東省杰出青年醫(yī)學人才廣東省杰出青年科學基金獲得者本科畢業(yè)于中山大學光華口腔醫(yī)學院即留校就職于中山大學孫逸仙紀念醫(yī)院口腔頜面外科（國家臨床重點專科）從事口腔頜面良惡性腫瘤的臨床治療以及基礎(chǔ)研究。近年來主要從事頜面軟硬組織數(shù)字化精準修復重建、顱頜面部內(nèi)鏡微創(chuàng)手術(shù)以及頭頸腫瘤的免疫治療。率先開展頜面-頭頸惡性腫瘤的新輔助免疫治療和輔助免疫治療，并取得了很好的臨床療效；在頜面腫瘤切除精準修復重建方面創(chuàng)立了制備超薄股前外側(cè)瓣的Honeycomb技術(shù)以及舌癌個性化半舌和標準全舌功能性修復重建的FIPELS技術(shù)，極大的推動力頜面腫瘤術(shù)后的功能和美觀的恢復；同時還在國際上首次開展經(jīng)頜下單一小切口內(nèi)鏡輔助下早期口腔癌擇區(qū)性頸淋巴清掃術(shù)以及內(nèi)鏡輔助經(jīng)顱耳溝徑路的腮腺微創(chuàng)手術(shù)，不僅保證腫瘤的切除效果且從根本上同時實現(xiàn)了微創(chuàng)和美觀并重?；A(chǔ)研究方面主要研究內(nèi)容包括頭頸部實體瘤的線粒體功能和免疫調(diào)控機制以及免疫治療。相關(guān)研究成果已以第一作者或通信作者在國外重要腫瘤學雜志《Clin Cancer Res》、《Cancer Res》、《Oncogene》、《Theranostics》、《Oral Oncol》、《Ann Surg Oncol》、《Plast Reconstr Surg》、《Surg Endosc》、《Head Neck》等發(fā)表SCI收錄論文40余篇，其中包括封面文章3篇以及ESI高被引論文。2016-2018年于哈佛大學麻省總院腫瘤外科進行博士后研究工作（頭頸癌免疫治療）。近年主持國家自然科學基金等各類項目8項，獲批經(jīng)費逾800萬元。獲中山大學青年教師重點培育項目以及“逸仙優(yōu)秀青年醫(yī)學人才”培養(yǎng)計劃；入選中山大學孫逸仙紀念醫(yī)院“高層次人才特別支持計劃”三個三青年拔尖人才項目。

社會任職

中華醫(yī)學會 委員

廣東省美容整形協(xié)會委員，2014年-至今廣東省醫(yī)學會頜面-頭頸外科學分會秘書，委員，2019-2023廣東省抗癌協(xié)會頭頸腫瘤專業(yè)委員會青年委員會副主任委員，2020-至今中國衛(wèi)生信息與健康醫(yī)療大數(shù)據(jù)學會口腔醫(yī)學專業(yè)委員會委員，2019-2023廣東省口腔頜面頭頸數(shù)字化精準修復重建工程技術(shù)研究中心副主任中國醫(yī)療保健國際交流促進會腫瘤整形外科與功能性外科分會青年委員，2016-至今廣東省醫(yī)學會顯微外科學分會第七屆委員會口腔頜面頭頸修復學組成員

獲獎榮譽

廣東省杰出青年醫(yī)學人才獲中山大學青年教師重點培育項目以及“逸仙優(yōu)秀青年醫(yī)學人才”培養(yǎng)計劃入選中山大學孫逸仙紀念醫(yī)院“高層次人才特別支持計劃”三個三青年拔尖人才項目

科研成果

以第一作者或通信作者在國外重要腫瘤學雜志《Clin Cancer Res》、《Cancer Res》、《Cancer Lett》、《Theranostics》、《Oral Oncol》、《Ann Surg Oncol》、《Plast Reconstr Surg》、《Surg Endosc》、《Head Neck》等發(fā)表SCI收錄論文30篇，其中包括封面文章3篇以及ESI高被引論文。近年主持國家自然科學基金等各類項目8項，獲批經(jīng)費逾800萬元。主要論著1. Peng Y#, Xiao L#, Rong H#, Ou Z, Cai T, Liu N, Li B, Zhang L, Wu F, Lan T, Lin X, Li Q, Ren S, Fan S*, Li J*. Single-cell profiling of tumor-infiltrating TCF1/TCF7+ T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer. Oral Oncol. 2021 May 25; 119:105348. (IF= 4.273)2. Lei X#, Ou Z#, Yang Z#, Zhong J#, Zhu Y#, Tian J, Wu J, Deng H, Lin X, Peng Y, Li B, He L, Tu Z, Chen W, Li Q, Liu N, Zhang H, Wang Z, Fang Z, Yamada T, Lv X, Tian T, Pan G, Wu F, Xiao L, Zhang L, Cai T, Wang X, Tannous BA, Li J*, Kontos F, Ferrone S*, Fan S*. A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3-Specific CAR T Cells in Solid Tumors. Clin Cancer Res. 2021 Apr 2. (IF=10.107)3. Zhang F#, Tang X#, Fan S#, Liu X#, Sun J, Ju C, Liang Y, Liu R, Zhou R, Yu B, Zhang C, Zhang Z, Kang T, Huang G*, Lv XB*. Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors. Oncogene. 2021 Jun;40(24):4137-4150. (IF: 7.971)4. Liu M#, Liu Q#, Fan S#, Su F, Jiang C, Cai G, Wang Y, Liao G, Lei X, Chen W, Bi J, Cheng W, Zhao L, Ruan Y*, Li J*. LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis. Cell Death Dis. 2021 Feb 1;12(2):144. (IF=6.304)5. Zhidong Sun#, Fan Wu#, Huichang Gao, Kai Cui, Mengyue Xian, Jianglong Zhong, Ye Tian, Song Fan*, and Gang Wu*. A Dexamethasone-Eluting Porous Scaffold for Bone Regeneration Fabricated by Selective Laser Sintering. ACS Applied Bio Materials. 2020 3 (12), 8739-8747 6. Zhao L#, Ye Y#, Jiao J#, Liao J, Lin Z, Zhong J, Wu J, Fang Z, Kontos F, Chen W, Huang X, Dias-Ribeiro E, Yang Z*, Li J, Fan S*. Comparison of postoperative cytokine and hormone between endoscopically assisted and open parotid tumor resection. Oral Dis. 2020 Nov 14. (IF=2.613)7. Julierme Ferreira Rocha, Song Fan, Eduardo Dias-Ribeiro. A new method to calculate the maximum dose of local anesthetics. Arch Health Invest .2020 9(3):210-210.8. Zhang L#, Li B#, Peng Y#, Wu F, Li Q, Lin Z, Xie S, Xiao L, Lin X, Ou Z, Cai T, Rong H, Fan S*, Li J*. The prognostic value of TMB and the relationship between TMB and immune infiltration in head and neck squamous cell carcinoma: A gene expression-based study. Oral Oncol. 2020 Nov;110:104943. (IF=3.979)9. Fan S*, Kontos F. Minimally Invasive Surgery: Straight Thinking and Still a Long Way to Go. Clin Surg. 2020; 5: 2733 10. Fan S#*, Tian T#, Lv X#, Lei X#, Yang Z, Liu M, Liang F, Li S, Lin X, Lin Z, Xie S, Li B, Chen W, Pan G, Lin X, Ou Z, Zhang Y, Peng Y, Xiao L, Zhang L, Sun S, Zhang H, Lin S, Li Q, Zeng B, Kontos F, Ruan Y*, Ferrone S, Lin D, Tannous BA and Li J*. lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter. iScience. 2020 Feb 21;23(2):100835. (IF= 4.447)11. Fu S#, Li JS#, Dias-Ribeiro E*, Palhano-Freire JC, Sun S, Fan S*. Aggressive Surgical Resection of Enormous Cervical Metastasis from Nasopharyngeal Carcinoma. Acta Stomatol Croat. 2019 Jun;53(2):168-173.12. Fan S#, Tian T#, Chen W#, Lv X#, Lei X, Zhang H, Sun S, Cai L, Pan G, He L, Ou Z, Lin X, Wang X, Perez MF, Tu Z, Ferrone S*, Tannous BA, Li J*. Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription. Cancer Res. 2019 Mar 15;79(6):1069-1084. (IF= 9.13)13. Tian T#, Lv X #, Pan G #, Lu Y #, Chen W #, Wang He, Lei X, Zhang H, Liu M, Sun S, Ou Z, Lin X, Cai L, He L, Tu Z, Wang X, Tannous BA, Ferrone S, Li J *, Fan S *. Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing. Clin Cancer Res. 2019 Jun 15;25(12):3673-3688. (IF= 10.199)14. Chen W#, Wang P#, Lu Y#, Jin T#, Lei X, Liu M, Zhuang P, Liao J, Lin Z, Li B, Peng Y, Pan G, Lv X, Zhang H, Ou Z, Xie S, Lin X, Sun S, Ferrone S, Tannous BA, Ruan Y*, Li J*, Fan S*. Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation. Theranostics. 2019 Aug 12;9(20):5739-5754. （IF= 8.06）15. Fan S#*, Zhang H#, Li Q#, Liang F, Bai Z, Chen W, Sun S, Yu P, Li J*. novel anatomy-based five-points eight-line-segments technique for precision subtotal tongue reconstruction: A pilot study. Oral Oncol. 2019 Feb;89:1-7. (IF= 4.636)16. Fan S#, Li QX#, Zhang HQ#, Liang MJ, Tian T, Wang YY, Lin ZY, Chen WX, Pan GK, Ahn MH, He L, Sun S, Wu BH, Yu P*, Li JS*. "Five-point eight-line" anatomic flap design for precise hemitongue reconstruction. Head Neck. 2019 May;41(5):1359-1366. (IF= 2.471)17. Zeng B#, Liao J#, Zhang H#, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J*, Fan S*. Novel ANO5 mutation c.1067G＞T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019 Jan;41(1):230-238. (IF= 2.471)18. Fan S#, Zhang HQ#, Li QX#, Tian T, Chen WX, Pan GK, Ho-Young Ahn M, Sun S, Wu BH, Li JS*. The Use of a Honeycomb Technique Combined with Ultrasonic Aspirators and Indocyanine Green Fluorescence Angiography for a Superthin Anterolateral Thigh Flap: A Pilot Study. Plast Reconstr Surg. 2018 Jun;141(6):902e-910e. (IF= 3.475)19. Zhang HQ#, Li QX#, Wang YY, Wang ZS#, Lin ZY, Sha LJ, Zhang DM, Liu J, Wang JJ, Li JS*, Fan S*. Combination of biomechanical evaluation and accurate placement of dental implants: a new concept of virtual surgery in maxillary and mandibular functional reconstruction. Br J Oral Maxillofac Surg. 2020 Jan;58(1):62-68. 20. Shen ZS#, Li JS#, Chen WL, Fan S*. The Latest Advancements in Selective Neck Dissection for Early Stage Oral Squamous Cell Carcinoma. Curr Treat Options Oncol. 2017 May;18(5):31. (IF= 3.562)21. Fan S#, Chen WX#, Lv XB#, Tang QL#, Sun LJ, Liu BD, Zhong JL, Lin ZY, Wang YY, Li QX, Yu X, Zhang HQ, Li YL, Wen B, Zhang Z, Chen WL, Li JS*. miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. Cancer Lett. 2015 Jul 1;362(2):183-91. (IF=6.491)22. Fan S#, Liu B#, Sun L#, Lv XB#, Lin Z#, Chen W, Chen W, Tang Q, Wang Y, Su Y, Jin S, Zhang D, Zhong J, Li Y, Wen B, Zhang Z, Yang P, Zhou B, Liang Q, Yu X, Zhu Y, Hu P, Chu J, Huang W, Feng Y, Peng H, Huang Q, Song E*, Li J*. Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis. Oncotarget. 2015 Jun 20;6(17):14885-904. 23. Fan S#, Pan GK#, Chen WL, Lin ZY, Liang FY, Li QX, Zhang DM, Wang YY, Zhang HQ, Chen WX, Chen R, Huang XM, Ye JT*, Li JS*. Endoscope-assisted extracapsular dissection of benign parotid tumors through a single cephaloauricular furrow incision versus a conventional approach. Surg Endosc. 2017 Aug;31(8):3203-3209. (IF=3.54)24. Xie SL#, Fan S#, Zhang SY#, Chen WX, Li QX, Pan GK, Zhang HQ, Wang WW, Weng B, Zhang Z, Li JS*, Lin ZY*. SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway. Int J Cancer. 2018 Mar 15;142(6):1252-1265. 25. Fan S#, Zhang DM#, Chen WL*. Endoscopy-Assisted Resection of Benign Lesions on the Base of the Tongue via the Transoral Approach Using a Harmonic Scalpel. J Oral Maxillofac Surg. 2017 Oct;75(10):2242-2247.26. Liang F#, Fan S#, Han P, Cai Q, Lin P, Chen R, Yu S, Huang X*. Endoscopic-assisted selective neck dissection via small lateral neck incision for early-stage (T1-2N0M0) head and neck squamous cell carcinoma: 3-year follow-up results. Surg Endosc. 2017 Feb;31(2):894-900. (IF=3.54)27. Fan S#, Wang YY, Lin ZY, Zhang DM, Yu X, Chen WX, Zhong JL, Li QX, Feng YH, Chen WL, Pan CB, Dias-Ribeiro E, Sonoda CK, Ye JT*, Li JS*. Synchronous reconstruction of bilateral osteoradionecrosis of the mandible using a single fibular osteocutaneous flap in patients with nasopharyngeal carcinoma. Head Neck. 2016 Apr;38 Suppl 1: E607-12. (IF=2.76)28. Fan S#, Wang YY, Wu DH, Lai DL, Feng YH, Yu X, Lin ZY, Zhang DM, Chen WL, Liang JQ, Li JS*. Intraoral lining with the fibular osteomyofascial flap without a skin paddle during maxillary and mandibular reconstruction. Head Neck. 2016 Apr;38 Suppl 1: E832-6. (IF=2.76)29. Fan S#, Liang FY#, Chen WL*, Yang ZH, Huang XM, Wang YY, Lin ZY, Zhang DM, Zhou B, Chen WX, Chai Q, Wang HJ, Pan CB, Liang QX, Yu X, Dias-Ribeiro E, Feng YH, Li JS*. Minimally invasive selective neck dissection: a prospective study of endoscopically assisted dissection via a small submandibular approach in cT(1-2_N(0) oral squamous cell carcinoma. Ann Surg Oncol. 2014 Nov;21(12):3876-81. (IF=3.66)30. Fan S#, Zhong JL#, Chen WX#, Chen WL*, Li QX, Wang YY, Lin ZY, Zhang HQ, Zhang DM, Yu X, Liang FY, Huang XM, Dias-Ribeiro E, Liu Y, Lin XH, Zhou B, Liang QX, Sonoda CK, Li JS*. Postoperative immune response and surgical stress in selective neck dissection: Comparison between endoscopically assisted dissection and open techniques in cT1-2N0 oral squamous cell carcinoma. J Craniomaxillofac Surg. 2017 Aug;45(8):1112-1116. (IF=1.59)31. Wang YY#, Fan S#, Zhang HQ, Lin ZY, Ye JT, Li JS*. Virtual Surgical Planning in Precise Maxillary Reconstruction With Vascularized Fibular Graft After Tumor Ablation. J Oral Maxillofac Surg. 2016 Jun;74(6):1255-64. (IF=1.63)32. Fan S#, Lin SG#, Zhang HQ#, Li QX, Chen WX, Wang YY, Zhang DM, Lin ZY, Zhong JL, Chen WL*, Li JS*. A comparative study of the endoscopy-assisted transoral approach versus external approaches for the resection of large benign parapharyngeal space tumors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Feb;123(2):157-162. (IF=1.26)33. Tang QL#, Fan S#, Li HG, Chen WL*, Shen XM, Yuan XP, Chang SH, Song Y. Expression of Cyr61 in primary salivary adenoid cystic carcinoma and its relation to Ki-67 and prognosis. Oral Oncol. 2011 May;47(5):365-70. (IF=4.29)34. Fan S#, Tang QL#, Lin YJ#, Chen WL*, Li JS, Huang ZQ, Yang ZH, Wang YY, Zhang DM, Wang HJ, Dias-Ribeiro E, Cai Q, Wang L. A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci. 2011 Oct;3(4):180-91. (IF=2.59)35. Fan S#, Chen WL*, Yang ZH, Huang ZQ.Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):359-63. (IF=1.26)36. Fan S#, Chen WL*, Pan CB, Huang ZQ, Xian MQ, Yang ZH, Dias-Ribeiro E, Liang YC, Jiao JY, Ye YS, Wen TY. Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):e89-93. (IF=1.63)37. Fan S*, Chen WL, de Lima-Júnior JL, Dias-Ribeiro E. Concerns about anesthetizing palatal tissues. J Oral Maxillofac Surg. 2011 Feb;69(2):574. 38. Ferreira-Junior O*, de Avila LD, Sampieri MB, Dias-Ribeiro E, Chen WL, Fan S*. Impacted lower third molar fused with a supernumerary tooth--diagnosis and treatment planning using cone-beam computed tomography. Int J Oral Sci. 2009 Dec;1(4):224-8. (IF=2.59)

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